Student Interest Group in Neurology (SIGN)

• Graduated medical school from Duke University
• Completed residency at Duke Children’s Hospital and Health Center
• Completed fellowship at Duke Children’s Hospital and Health Center
• Director of the Leukodystrophy Clinic at Nationwide Children’s Hospital
• Current research includes case series of various prenatally-identified brain malformations; a leukodystrophy case series; potential research related to communication with families affected by leukodystrophies
• Research area: Neurogenetics, Neonatal/fetal, Education
• Clinical research projects available
• Open to mentoring: current neurology resident or fellow, current neurology pre-lim, medical students

• Graduated medical school from Rush Medical College
• Completed residency at Johns Hopkins Hospital
• Completed fellowship at Johns Hopkins Hospital and University of Utah Medical School
• Director of the Center for Gene Therapy in The Research Institute at Nationwide Children’s Hospital
• Current research includes a wide range of projects ranging from clinical datasets to basic science projects exploring gene delivery and gene correction for various forms of muscular dystrophy; the specific project will depend upon the trainee and the amount of time they will be able to commit
• Research area: Neuromuscular, Gene therapy
• Clinical and basic science research projects available
• Open to mentoring: current neurology resident or fellow, current neurology pre-lim, medical students

From Dr. Flanigan: “I am the director of the Nationwide Children’s Hospital (NCH) Center for Gene Therapy, as well as director of the NCH Neuromuscular Program and its neuromuscular and multidisciplinary Muscular Dystrophy clinics.  I am also director of the NCH NIAMS P50-funded Center of Research Translation in Muscular Dystrophy Therapeutics.

I trained in Neurology (residency) and Neuromuscular Disease (fellowship) at the Johns Hopkins Hospital before doing a laboratory-based fellowship in Molecular Biology and Genetics at the University of Utah, where I joined the faculty prior to moving to Columbus in 2009.

I founded and have since 2012 directed the NCH/OSU Myology Course, direct the OSU/NCH Neuromuscular Fellowship program pediatric component, and established the NCH GME-approved Neuromuscular Genetic Therapeutics (now Gene Therapy) fellowship.  My work is primarily funded by the NIH, with additional biopharma partner sponsored research agreements and foundation funding.

The overall mission of my laboratory is to rapidly advance translational therapies for neuromuscular and neurologic diseases.  Our particular emphasis is on the muscular dystrophies and congenital myopathies.

Our laboratory is concentrating on two major overarching themes.

The first is understanding molecular mechanisms by which patients with muscular dystrophy – why, for example, certain patients who are expected to make no dystrophin and have severe Duchenne muscular dystrophy instead have mild Becker muscular dystrophy.  We are cataloging clinical features, protein expression studies from muscle biopsies using cutting-edge microscopy and capillary immunoassay techniques, and RNA Sequencing studies.

The second is to sidestep the limitation imposed by adeno-associated viruses (AAVs) regarding gene length that require delivery of engineered microdystrophin constructs, and to leapfrog to methods for expressing full-length, wild-type dystrophin.  We use a variety of techniques, include CRISPR/Cas gene editing, and U7snRNA pre-mRNA splice alteration (the latter of which is already in clinical trial).

The range of our work is found here: https://www.ncbi.nlm.nih.gov/myncbi/k.flanigan.1/bibliography/public/

There are no pre-requisites.  The level of independence for a given project will depend on prior experiences.

There are no time frame restrictions.  Any trainee is expected to pre-define a work schedule with immediate mentors (which may include lab technicians, clinical research coordinators, graduate student, or post-doctoral trainees) and within reason will be expected to commit to that schedule in order to maximize their meaningful exposure to research.”

• Graduated medical school from Duke University
• Completed residency at Lurie Children’s Hospital
• Completed fellowship at Lurie Children’s Hospital and Nationwide Children’s Hospital
• Director of Critical Care Neurology within the Section of Neurology
• Director of the Neuro-ICU Follow-Up Clinical at Nationwide Children’s Hospital
• Research area: Cerebrovascular, Neurocritical care
• Clinical research projects available
• Open to mentoring: current neurology resident or fellow, current neurology pre-lim, medical students

• Graduated medical school from John Hopkins School of Medicine
• Completed residency at Children’s Hospital of Philadelphia
• Completed fellowship at Children’s Hospital of Philadelphia
• Director of the Neuroimmunology Clinic at Nationwide Children’s Hospital
• Research area: Neuroimmunology
• Clinical research projects available
• Open to mentoring: current neurology resident or fellow, current neurology pre-lim

• Graduated medical school from the University of Iowa
• Completed residency at St. Louis Children’s Hospital
• Completed fellowship at St. Louis Children’s Hospital
• Research area: Epilepsy/seizure, Neurogenetics, Quality improvement
• Clinical and basic science research projects available
• Open to mentoring: current neurology resident or fellow, current neurology pre-lim, medical students

• Graduated medical school from Baylor College of Medicine
• Completed residency at Baylor College of Medicine
• Completed fellowship at University of Texas Southwestern Medical Center
• Current research includes evaluation of thalamic involvement in seizure onset and propagation using intracranial EEG findings (along with Dr. Shaikhouni); survey of national trends in epilepsy surgical management (along with Drs. Ostendorf and Ahrens); neonatal EEG inter-rater reliability between EEG technicians
• Research area: Epilepsy/seizure, TSC, Epilepsy surgery
• Clinical research projects available
• Open to mentoring: current neurology resident or fellow

From Dr. Arredondo:

“Current projects include:

• Neonatal/NICU EEG evaluation of tech inter-rater reliability in identifying seizures and background features (preliminary stages)
• Treatment trend evaluation using national survey of epilepsy surgery utilization in all level 3 and 4 NAEC epilepsy centers in the US (mid stages)
• Intracranial EEG findings from patients with thalamic EEG monitoring as part of evaluation of thalamocortical connectivity (ongoing)

Open to: any interesting case studies of epilepsy patients, genetic epilepsies, interesting EEG findings

Pre-requisite experience: Child neuro resident, any level of training, ideally some EEG exposure thus far or interest in EEG though this is not required

Time frame: No specific restrictions

Please feel free to contact me with interest for more details.”

• Graduated medical school from Case Western Reserve University School of Medicine
• Completed residency at Seattle Children’s Hospital
• Completed fellowship at Seattle Children’s Hospital
• Current research includes (1) examining health disparities in epilepsy and how that relates to access to surgical evaluation, and (2) examining QOL in epilepsy and specifically how social determinants are related
• Research area: Epilepsy/seizure
• Clinical research projects available
• Open to mentoring: current neurology resident or fellow, current neurology pre-lim, medical students

• Graduated medical school from the University of Minnesota
• Completed residency at Mayo Clinic (Rochester)
• Completed fellowship at the NIH Neurological Institute
• Co-Director of the Neuroimmunology Program at Nationwide Children’s Hospital
• Magana is open to mentoring committed trainees, but given the significant methods training, would require at least one year commitment after completing a one month rotation
• Research area: Neuroimmunology
• Clinical and basic science research projects available
• Open to mentoring: current neurology resident or fellow, current neurology pre-lim, medical students

• Graduated medical school from Nova Southeastern University
• Completed residency at Nicklaus Children’s Hospital (formerly Miami Child)
• Completed fellowship at University of Chicago Children’s Hospital and Nationwide Children’s Hospital
• Director of the Psychogenic Nonepileptic Events Clinic in the Pediatric Epilepsy Center at Nationwide Children’s Hospital
• Associate Program Director of the Child Neurology Residency Program
• Co-Director of the Clinical Neurophysiology Fellowship Program
• Current research includes ongoing projects and ideas for future projects in PNEE, neurology education; Quality improvement work is ongoing but is more sporadic
• Research area: Epilepsy/seizure, Medical education, Neurology Education, Quality improvement
• Clinical research projects available
• Open to mentoring: current neurology resident or fellow, current neurology pre-lim, medical students